DS1621+ NAS with Ryzen CPU Review

Welcome to the future of data storage with the Synology DiskStation DS1621+ NAS Server. This robust, high-capacity server offers a perfect blend of power and scalability, making it a fantastic fit for small to medium-sized businesses that need to handle intensive, multi-user workloads. Equipped with a Ryzen V1500B Quad-Core 2.2GHz CPU, 32GB DDR4 memory, and a substantial 48TB HDD storage, the DS1621+ ensures rapid and efficient data processing and storage. Whether you’re setting up an iSCSI target backup, managing large file storage, or hosting an email server, this NAS server is designed to meet your diverse needs with an array of features including cache acceleration, virtual machine management, and top-notch security measures. Let’s explore how the Synology DiskStation DS1621+ can transform your data management experience, offering unparalleled performance and reliability in one compact system. Have you ever wondered how you can manage your growing data needs effortlessly? If you’re searching for a reliable, high-performance NAS server, the Synology DiskStation DS1621+ NAS Server with Ryzen 2.2GHz CPU, 32GB Memory, 48TB HDD Storage, and 1TB M.2 NVMe SSD might just be the answer to your prayers. Let’s dive right in and explore what this powerful piece of technology has to offer.

Synology DiskStation DS1621+ NAS Server with Ryzen 2.2GHz CPU, 32GB Memory, 48TB HDD Storage, 1TB M.2 NVMe SSD, 4 x 1GbE LAN Ports, DSM Operating System

Get your own Synology DiskStation DS1621+ NAS Server with Ryzen 2.2GHz CPU, 32GB Memory, 48TB HDD Storage, 1TB M.2 NVMe SSD, 4 x 1GbE LAN Ports, DSM Operating System today.

Overview of Synology DiskStation DS1621+

Let’s start with an overview. The Synology DiskStation DS1621+ is a robust NAS server built for versatility and high-performance. It is ideal for small and medium-sized businesses that need to handle intensive, multi-user workloads.

Key Features

Powerful Processing

The heart of this NAS server is the Ryzen V1500B Quad-Core 2.2GHz CPU. This processor brings speed and efficiency to your data management, ensuring that even the most demanding tasks are handled effortlessly. Whether you are running multiple virtual machines, performing backups, or managing large file storage, the DS1621+ has got you covered.

Massive Storage Capabilities

With 48TB of HDD storage (6 x 8TB SATA 3.5″ HDDs) and 1TB of ultra-fast M.2 NVMe SSD storage (2 x 500GB), the DiskStation DS1621+ provides ample space for all your data needs. The device offers a unique blend of high-capacity storage and fast performance.

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Below is a table for a quick glance at the storage specifications:

Type Capacity Configuration
HDD Storage 48TB 6 x 8TB 3.5″ SATA
SSD Storage 1TB 2 x 500GB M.2 NVMe

High Memory for Intensive Tasks

With 32GB of DDR4 ECC SODIMM memory, the DiskStation DS1621+ is built to handle intensive tasks without breaking a sweat. This high memory capacity ensures smooth operation and quick responsiveness, particularly useful in multi-user environments.

Connectivity Options

One of the strengths of DS1621+ is its extensive connectivity options. It has 4 x 1GbE LAN ports that support link aggregation and failover, ensuring that your network remains reliable and fast. Additionally, it offers 3 x USB 3.2 ports and 2 x eSATA ports for connecting accessories and extending the system.

DSM Operating System

The DiskStation Manager (DSM) operating system simplifies your storage management. DSM offers various applications and services such as Synology High Availability, Virtual Machine Manager, Central Management System, and more. The user-friendly interface ensures you have complete control over your NAS server.

Performance and Functionality

iSCSI Targets and Backup

The DS1621+ excels at being an iSCSI target, making it perfect for server backup solutions. It provides excellent read/write speeds, making sure that your data is always accessible when you need it. Furthermore, features like Active Backup for VMware, Windows, Office 365, and G Suite make it a versatile backup solution.

Large File Storage

Managing large files is a breeze with its massive storage capacity and ultra-fast SSD caches. If you work with graphics, videos, or large datasets, you’ll appreciate the seamless performance and ease of access.

Domain Controllers and Email Servers

The DS1621+ fits effortlessly into business environments, capable of serving as a domain controller and email server through Synology MailPlus. It ensures that all business communications and data management needs are concentrated in one powerful device.

Synology DiskStation DS1621+ NAS Server with Ryzen 2.2GHz CPU, 32GB Memory, 48TB HDD Storage, 1TB M.2 NVMe SSD, 4 x 1GbE LAN Ports, DSM Operating System

Get your own Synology DiskStation DS1621+ NAS Server with Ryzen 2.2GHz CPU, 32GB Memory, 48TB HDD Storage, 1TB M.2 NVMe SSD, 4 x 1GbE LAN Ports, DSM Operating System today.

Security Features

AES 256-bit Encryption and 2-Factor Authentication

Security is a priority, and the DS1621+ does not fall short in this department. It offers AES 256-bit encryption for safeguarding your data. Additionally, 2-Factor Authentication ensures that unauthorized access is minimized, providing you with peace of mind.

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Additional Features

Cache Acceleration

With M.2 NVMe SSD slots, you can significantly accelerate cache processing, drastically improving read/write speeds and overall system responsiveness. This feature is invaluable for tasks requiring high-speed data access.

Virtual Machine Manager

The ability to manage multiple virtual machines makes the DS1621+ an ideal solution for businesses requiring isolated environments for different applications. Whether for testing, development, or running different operating systems, the Virtual Machine Manager simplifies virtual environment management.

Multimedia Server Role

Thanks to its robust processing and high storage capacity, DS1621+ can serve as a 4K multimedia server, ensuring smooth streaming and media handling.

Pros and Cons

Let’s break down the pros and cons of the Synology DiskStation DS1621+:


  • High processing power with Ryzen V1500B Quad-Core 2.2GHz CPU
  • Massive storage capacity and ultra-fast SSD cache
  • Extensive connectivity options
  • Powerful memory for multi-user environments
  • Highly secure with AES 256-bit encryption and 2-Factor Authentication
  • Versatile DSM operating system with various applications
  • Supports multiple server roles


  • Installation of hard drives and memory upgrades required
  • Initial setup might be complex for novice users

Setting Up Your Synology DiskStation DS1621+

Step-by-Step Installation

Although hard drives and memory upgrades come separately and not installed, setting it up is straightforward. Here’s a brief rundown on getting started:

  1. Unbox the Device: Carefully unbox your DS1621+ and ensure all components are present.

  2. Install HDDs: Open the front panel and insert the 3.5″ SATA HDDs into the drive bays. Secure the drives in place.

  3. Install M.2 SSDs: Open the slot covers on the bottom of the device and insert the M.2 NVMe SSDs.

  4. Connect to Network: Plug in the power adapter and connect the NAS server to your network using the LAN ports.

  5. Initialize DSM: Power on the device and follow the on-screen instructions to initialize DiskStation Manager.

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Quick Tips

  • Firmware Upgrade: Always check for the latest firmware updates to ensure optimal security and performance.
  • Backups: Configure regular backups to protect your data from unexpected loss.
  • use: Use Link Aggregation to enhance network performance if supported by your environment.

Real-World Applications

Small and Medium Businesses

For small and medium-sized businesses, the DS1621+ serves as a multifunctional server, handling email hosting, file storage, and domain services efficiently. The extensive memory and storage make it ideal for environments with multiple users.

Creative Professionals

If you work with high-resolution media files, the DS1621+ offers a seamless experience for storing, editing, and streaming large files. The fast SSD cache ensures you don’t experience lag or delays.

Home Enthusiasts

Even home users who need lots of storage for multimedia, backups, and personal files can benefit from the DS1621+. Its user-friendly DSM interface ensures everyone, regardless of tech-savviness, can use it without trouble.

Troubleshooting Common Issues

Here are some common issues you might encounter and their solutions:

Connectivity Problems

  • Issue: Device not found on the network.
  • Solution: Make sure all cables are connected properly and check the network settings in the DSM.

Slow Performance

  • Issue: System feels sluggish.
  • Solution: Verify that you’re utilizing SSD caching efficiently and check for any background tasks that may be consuming resources.

Final Thoughts

The Synology DiskStation DS1621+ NAS Server offers incredible value with its high-capacity storage, powerful CPU, ample memory, and versatile features. As you saw, it’s suitable for a wide range of applications in small and medium businesses, as well as for creative professionals and home enthusiasts.

I hope this review helps you decide whether the DS1621+ is the right choice for you. If you’re looking for a reliable and powerful NAS server, you won’t regret choosing the Synology DiskStation DS1621+.

Feel free to reach out if you have any questions or need further information. Happy data managing!

Learn more about the Synology DiskStation DS1621+ NAS Server with Ryzen 2.2GHz CPU, 32GB Memory, 48TB HDD Storage, 1TB M.2 NVMe SSD, 4 x 1GbE LAN Ports, DSM Operating System here.

Disclosure: As an Amazon Associate, I earn from qualifying purchases.

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About the Author: Dave Taylor

Dave's technical acumen extends beyond server hardware. He possesses an in-depth understanding of various operating systems, including Windows Server, Linux, and UNIX, enabling him to tackle intricate software configurations and resolve compatibility challenges effectively.